High-resolution cryo-electron microscopy makes it possible to study complex enzymatic processes in detail. With this method, a research team of the University of Potsdam and Humboldt-Universität ...

An investigational PCSK9 inhibitor with a different mechanism from existing drugs in this class has been shown to safely and effectively lower cholesterol levels.

Since ACAT2 converts acetyl-CoA to acetoacetyl-CoA, a precursor of HMG-CoA in the mevalonate pathway that drives cholesterol biosynthesis, we aim to explore cholesterol’s potential role in this ...

"The study highlights how cholesterol regulation not only explains differences between people's vulnerability to Alzheimer's, but also differences in vulnerability between brain regions at early ...

Investigators found that lipid metabolism disruptions spark T-cell dysfunction in patients with chronic lymphocytic leukemia.

Cholesterol metabolism byproduct linked to Parkinson’s disease Hydrocholesterol 24-OHC associated with dopamine neuron degeneration and Levy body formation Peer-Reviewed Publication PLOS ...

SLC13A2 increased cleavage of SREBP2, and expression of cholesterol metabolism genes, including LDLR and HMGCR. Mechanistically, SLC13A2 promotes import of citrate into hepatocytes, serving as ...

One class of drugs, called statins, is already very widely used to control cholesterol levels. Statins work by blocking a protein in the cholesterol biosynthesis pathway called HMGCR.

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the ...

To exclude the possibility that glutamine-starvation decreased cholesterol synthesis through an indirect effect on glucose metabolism, we next incubated cells with 14 C-acetate, which is incorporated ...

These findings indicate that propionyl-CoA and acetyl-CoA bind to PCC with a similar binding mode.” Comment 3: The authors also need to be careful with their over-interpretation of structure to invoke ...