They used an adenovirus-associated virus (AAV) to deliver a gene editor for deleting SATB2 andshowed that the treated colon organoids became ileum-like and were able to survive when transplanted ...

In the study, "Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease," published on the bioRxiv preprint server, researchers performed a ...

For decades, the Amphibious Assault Vehicle (AAV) has been a cornerstone of the U.S. Marine Corps, transporting troops and cargo from ship to shore. With its 29-ton combat weight, armored ...

Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.

The AAV-Ep+ capsid variant was identified through a massively parallelled and unbiased screen of a large-diversity AAV variant library administered to NHPs.

Amid a reckoning for the gene therapy field, Vertex Pharmaceuticals has joined a growing list of companies paring back their research efforts around the adeno-associated virus (AAV) vectors used ...

TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models.

AAV Vectors AAVs are single-stranded DNA viruses that require co-infection with other viruses, mainly adenoviruses, to replicate. When used as gene therapy vehicles, researchers generate recombinant ...

Challenges in AAV titer Multiple methods have been developed and employed in recent years to improve genome titer and AAV quantitation.

Click here to read the article now. Developing AAV capsids with improved yield, or fitness, is a key strategy for reducing manufacturing costs in order to make gene therapies more affordable.

The AAV-7A1 Amtrac is a US Transport Vehicle that seats up to six players. This Amphibious Assault Vehicle can drive on both land and sea, making it a very useful vehicle for bringing soldiers ...

AAV-sTREM2 PS19 mice were created to study the long-term effects of soluble TREM2 (sTREM2) in the context of tauopathy (Zhang et al., 2023). To generate this model, AAV carrying cDNA encoding EGFP- ...