In other words, drugs that can selectively promote the protective functions of Mst1 would help protect cardiac myocytes in the case of life-threatening conditions such as heart failure.

Mathematical models of the bioelectric activity in the cardiac conduction system can be used to study the impact of drugs, conduct hypothetical experiments, and for closed-loop validation of cardiac ...

By controlling the duration of the cardiac action potential in adult CMs, the biophysical properties of Ca (v)1.2 directly influence the QT interval (9, 10, 37, 38)—a critical determinant of cardiac ...

Keywords: drug testing, patch clamp, human, cardiac myocytes, left atrial appendage, action potential, dynamic clamp, inward rectifier potassium current Citation: Verkerk AO, Marchal GA, Zegers JG, ...

Adjacent cardiac myocytes are linked via intercalated discs (ICDs) consisting of desmosomes, adherens junctions, and gap junctions. 1 Desmosomes, together with adherens junctions, provide cardiac ...

Rationale:Monitoring and controlling cardiac myocyte activity with optogenetic tools offer exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage ...

Rationale:Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular level alternans manifests as beat-to-beat alternations in contraction, action potential ...

Since publication of the first computational model of the cardiac myocyte action potential (AP) in 1960 (Noble, 1960), the range of biological processes described in models of the cardiac myocyte has ...

Abstract The plasma membrane of cardiac myocytes presents complex invaginations known as the transverse-axial tubular system (TATS). Despite TATS's crucial role in excitation-contraction coupling and ...

A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in ...