Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to engineer potent, protease-stable single-domain antibodies to enable oral ...

An antibody modified terahertz (THz) metamaterial biosensor is proposed to detect the concentration of carcinoembryonic antigen (CEA). The biosensor has four metal split-ring-resonators (SRR) in a ...

In the context of fast and significant technological transformations, it is natural for innovative artificial intelligence (AI) methods to emerge for the design of bioactive molecules. In this study, ...

Single-domain antibodies (sdAbs), also known as VHH antibodies or camelid antibodies, are derived from the immune systems of camels and llamas. Unlike conventional antibodies, the unique structure ...

Development of different platforms would be useful for designing functional antibodies to improve the efficiency of antibody-based drugs. Three-dimensional domain swapping (3D-DS) may occur in the ...

In a paper recently published on hLife, Chinese scientists elucidate the 3.04 Å cryo-EM structure of HSV-1 gB bound to the neutralizing antibody D48. Through structural and sequence comparison ...

Nanobodies, also known as single-domain antibodies (sdAbs) or VHH antibodies, are only 1/10th the size of traditional monoclonal antibodies but can retain full antigen-binding potential, establishing ...

Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43443-4 ...

On the other hand, 3D-DS may promote aggregation of antibodies. Hirota concludes: “These findings not only clarify the domain-swapped structure of the antibody light chain but also contribute to ...