When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there ...

Using AI and Multiplexed Gene Fragments, researchers developed a novel design approach to encode thousands of single-domain ...

Database search is the most commonly employed method for identification of peptides from MS/MS spectra data. The search involves comparing experimentally obtained MS/MS spectra against a set of ...

Although scientists have made significant progress in understanding the disease, there’s still no cure. That’s partly because ...

Fit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Arano and co-workers (Arano et al. (1999) Cancer Res. 59, 128−134) have synthesized peptides with an N-terminal radioiodinated hippuric acid and a C-terminal lysine linked to antibody fragments via ...

Antibody-drug conjugates (ADCs) represent a mechanistically defined class of targeted therapeutics that combine monoclonal antibodies with cytotoxic payloads to achieve selective delivery to ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Article Published: May 2001 Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity Seung-Jun Kim, Dae-Gwin Jeong, Seung-Wook Chi, Jin-Sook Lee ...

Fifty years after F. Macfarlane Burnet published his seminal paper on the clonal-selection theory of antibody diversity, six key scientists provide their thoughts and opinions on how this theory ...