Natural nucleic acids like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L-aTNA remain the same, they have an amino ...

Artificial nucleic acids with a fixed conformation of the backbone of the oligonucleotide can form stable duplexes, however, the synthesis of modified nucleotides with non-canonical three ...

Sugar: In DNA, the sugar is deoxyribose, while in RNA, it is ribose.The sugar forms the backbone of the nucleic acid strand. Phosphate Group: The phosphate group is attached to the sugar and helps ...

Xeno nucleic acids are essential for the development of nucleic acid-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA ...

A biochemical breakthrough using simple carbon atoms, by Ken Yamada, Ph.D., and Anastasia Khvorova, Ph.D., has dramatically improved the stability and efficacy of a potential oligonucleotide ...

Summary Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University of ...

Nucleic acids are essential for the functioning and development of living organisms. DNA carries genetic information that determines traits such as eye color and susceptibility to diseases in ...

WEST LAFAYETTE, Ind. — A researcher in Purdue University’s College of Science is developing a patent-pending platform technology that mimics the dual-layer structure of viruses to deliver nucleic acid ...

“Nucleic acid molecules are shielded by nanoparticle delivery systems.” In their review, the authors summarized recent studies on nanoparticle-mediated cancer immunotherapy.

Back in the bad old days, dealing with DNA and RNA in a lab setting was often fraught with peril. Detection technologies were limited to radioisotopes and hideous chemicals like ethidium bromide, a… ...

A new study finds that 19 amino acids essential to life on Earth are stable for up to four weeks when placed in vials of sulfuric acid at concentrations similar to those in Venus’ clouds.