A print book should have "Facing Pages" checked, and an e-book should not. Check the "Master Text Frame" option if you plan to use page numbers, footers or headers on each page.

Book designer and author Joel Friedlander takes a look at pitfalls self-publishers face when doing their own book formatting, and explains how to avoid these mistakes in the first place.

With the clever use of fonts and layout, ... In an effort to reduce the carbon footprint of each book, they’re tweaking fonts, layout, ... It would also cut HarperCollins’s printing costs.