Efficacy and Tolerability of Meloxicam, a COX-2 Preferential Nonsteroidal Anti-Inflammatory Drug M. Del Tacca, R. Colucci, M. Fornai, C. Blandizzi Disclosures Clin Drug Invest. 2002;22 (12) 0 ...

Introduction: Therapeutic strategies to treat chronic pancreatitis (CP) are very limited. Other chronic inflammatory diseases can be successfully suppressed by selective cyclooxygenase 2 (COX-2) ...

Given the crucial role of synovial macrophages in OA, the mechanism by which Imrecoxib protects joint cartilage and treats OA through the regulation of macrophage polarization deserves further ...

eLife Assessment This study presents important findings on the role of pyramidal cells driving vasoconstriction in brain arteries through a COX-2/PGE2 pathway, with additional contributions from NPY ...

COX-2 inhibitors, also known as selective COX-2 inhibitors, are nonsteroidal anti-inflammatory drugs (NSAIDs) that treat inflammatory pain. They’re available by prescription and may be easier on ...

After labeling their fastest-binding compounds with carbon-11, the researchers tested the molecules in rats injected with a virus engineered to express COX-2. They found that the strongest signal ...

The specific factors involved in COX‐2 activation depend on both the cell type and the stimulus. Thus, NF‐κB contributes to COX‐2 induction in some, but not all, cell types. Although LPS engages NF‐κB ...

Peripheral blood mononuclear cells (PBMCs) were isolated for macrophage cell culture. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, was used to inhibit prostaglandin E2 (PGE2 ...

Inflammation-related diseases affect large populations of people in the world and cause substantial healthcare burdens, which results in significant costs in time, material, and labor. Preventing or ...

Rather SARS-CoV-2 entry in macrophages was facilitated by a lectin, CD169, which recognizes the spike protein of SARS-CoV-2." Suryaram Gummuluru, PhD, corresponding author, professor of microbiology ...