Mice with macrophage-specific deletion of the major PGE 2 receptor, EP 4, also developed salt-sensitive hypertension, with aberrant macrophage polarization and increased NCC activity.

(HealthDay)—Macrophage cyclooxygenase-2 (COX-2) deletion is associated with progression of diabetic nephropathy (DN), according to an experimental study published online Nov. 4 issue of Diabetes.

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, was used to inhibit prostaglandin E2 (PGE2) expression in these cells. ... (RT-qPCR) was performed to assess macrophage polarization.

In a study in mice, the Vanderbilt researchers found that when the COX-2 enzyme in macrophages was blocked, and thus prevented from making prostaglandins, hypertension and edema got worse.

BURBANK, Calif., Oct. 12, 2021 (GLOBE NEWSWIRE) -- via NewMediaWire – Medolife Rx, Inc. ("Medolife"), a global integrated biopharmaceutical company with R&D, manufacturing, and consumer product ...

Moreover, CS concomitantly promoted transition of M1 macrophages to M2 macrophages with increased oxidative phosphorylation, thus indicating that macrophage polarization may also be a potential ...