We developed an ex vivo co-culture system to interrogate pharmacologic or genetic perturbations that modulate anti-cancer immunotoxicity in CRC. Methods: Our system uses expanded CD8+ TILs & ...

They set up a realistic ex vivo co-culture system composed of the primary fibroblasts and normal colon 3-D organoids, both directly from human patients, or colon adenoma and CRC cell lines. The ...

The -SG diet inhibited the growth of CRC cells in culture. The anti-proliferative effect was coupled with a delay in entering the synthetic phase of the cell cycle.

Methods: The cells of Caco-2, HT-29, and HCT 116 cultures were encapsulated in 1% alginate beads at a concentration of 100 000 cells/ml. Subsequently encapsulated cells were kept in 2 variants of ...

To access the performance of a cell-free DNA blood-based CRC screening test in an average-risk population, Chung and colleagues conducted the ECLIPSE trial, enrolling adults aged 45 years and ...

CellMax Life published results from a study showing its circulating tumor cell blood test accurately detected colorectal cancer and precancerous lesions at an 87 percent and 77 percent accuracy rate, ...

There were 7470 (95% uncertainty interval [UI], 6606-8322) cases of CRC and 3624 (95% UI, 3211-4030) deaths due to CRC that occurred in a cohort of 100,000 individuals without screening beginning ...

Distant metastasis and drug resistance are the main causes of colorectal cancer (CRC)-derived mortality. Identifying the underlying mechanisms driving metastasis is key for improving its therapy.

A cell-free DNA (cfDNA) blood test, aimed at detecting abnormal DNA signals in people with an average risk of colorectal cancer (CRC), correctly detected CRC in most people confirmed to have the ...

DDX10 deletion promotes CRC cell apoptosis through ATG10-driven autophagy. Aug. 21, 2024. No Comments. Colorectal cancer (CRC) is rated as the second most deadly cancer after lung cancer. Identifying ...