Microglia are specialized immune cells that make up around 10 % of all cells in the brain and spinal cord. They work by removing pathogenic bacteria, dead cells, aggregated proteins, and soluble ...

Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated ...

This new approach to gene editing could lead to faster personalized therapies for this and other rare diseases. Another advantage, the doctors pointed out, is that it can be given again later in ...

Figure 3. Differential gene expression (DGE) analysis of CX3CR1+ resident microglia and CCR2+ infiltrating cells sorted from the hypothalamus of HFD-fed mice show an enormous difference in their ...

Alzheimer's disease (AD) is the most common neurodegenerative disease, and it consumes considerable medical resources with increasing number of patients every year. Mounting evidence show that the ...

Alzheimer's disease (AD) is the most common neurodegenerative disease, and it consumes considerable medical resources with increasing number of patients every year. Mounting evidence show that the ...

Purpose Few reliable prognostic molecular markers have been characterized for glioblastoma multiforme (GBM), considered the deadliest of human cancers. We hypothesized that genetic polymorphisms in ...

The correlation heatmap is shown as Figure 2A. 61 CX3CR1-related genes were analyzed by gene ontology functional annotation analysis. CX3CR1-related genes were mainly concentrated on intracellular ...

Mice devoid of the CCR2 gene expression exhibit markedly reduced recruitment of monocytes to sites of inflammation (14). CX3CR1, is also an important chemokine receptor for monocytes and macrophages.

Previously, we showed hippocampal reduction of fractalkine receptor (Cx3cr1) mRNA at prenatal day (P) 15 in male offspring exposed to maternal immune activation induced with lipopolysaccharide (LPS) ...

Herein, a novel example demonstrates that polymers of human ZZ alpha-1 antitrypsin (Z-AAT) protein, resulting from its conformational misfolding due to the Z (Glu342Lys) mutation in SERPINA1 gene, ...