Reviewer #2 (Public review): The manuscript from Shan et al., sets out to investigate the role of Chi3l1 in different hepatic macrophage subsets (KCs and moMFs) in MASLD following their identification ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

CX3CR1+ cells generate tissue macrophages in the developing heart and play cardioprotective roles in response to ischemic injuries in the adult heart. However, the origin and fate of CX3CR1+ cells ...

Gene set enrichment analysis of the transcriptome of resident aortic macrophages, obtained by Affimetryx, 14 and our integrated scRNA-Seq data set indeed showed that vascular macrophages of healthy ...

Objective— Dendritic cells (DCs) have recently been found in atherosclerosis-predisposed regions of arteries and have been proposed to be causal in atherosclerosis. The chemokine receptor CX3CR1 is ...

Alsheebani's care team at The James, led by Dr. Marcos de Lima and Dr. Roberta Azbell, employed gene therapy to treat Alsheebani's illness by injecting him with a medication that allows stem cells ...

CINCINNATI (Cincinnati Business Courier) - Backed by big money and aggressive plans to manufacture cutting-edge gene and cell therapies, a biomanufacturer made big promises about a revolution in ...

Microglia are specialized immune cells that make up around 10 % of all cells in the brain and spinal cord. They work by removing pathogenic bacteria, dead cells, aggregated proteins, and soluble ...

Experiments in mice reveal an early postnatal window of opportunity for the effective transfer of genes to blood-cell-producing haematopoietic stem cells by injecting mice with gene-carrying ...

Before gene therapy, the median annualized bleeding rate was 14.0 episodes (IQR, 12.0 to 21.5) among all 10 participants, including 3 participants who were receiving on-demand treatment.