In non-human primate (NHP) studies to date, a single IV infusion of CAP-003 resulted in dose-dependent increases in GCase activity in critical brain regions including the substantia nigra, frontal ...

Women with anorexia had higher levels of mu-opioid receptor availability in key areas of the brain involved in reward processing, such as the caudate, putamen, and nucleus accumbens.

The striatum can be further subdivided into dorsal (caudate, putamen) and ventral (nucleus accumbens), and is implicated in regulating motor behaviours and responses to rewarding and aversive stimuli.

Nucleus Software appoints Aabhinna Suresh Khare as Chief Marketing Officer He has previously held senior roles at Bajaj Capital, BookMyForex, IndiaMart, Travel Triangle, and Star & Zee Networks.

The location of lesions includes the caudate nucleus, putamen, thalamus, subthalamus, globus pallidus, corona radiata and subcortical white matter. 11, 12 The chorea will have resolved in ...

There’s a new kid on the block in the fast-growing radiopharmaceuticals category, as Nucleus RadioPharma chalks up an oversubscribed Series A that raised $56 million that will b ...

For instance, cortical surface reconstruction maps show that regional cortical thinning in pre-HD remains when adjusting for caudate and putamen volumes (Figure 3). [25] ...

Meanwhile, another Bayer subsidiary – AskBio – has started randomising the first patients in its phase 2 trial of AB-1005 (AAV2-GDNF), which delivers a gene into the putamen region of the ...

The radioligand [11C] N-methylspiprone (NMSP) has been used to assess relative and absolute D2 dopamine receptor densities in the living human brain with positron emission tomography (PET). In those ...

We explored whether white matter organisation principles known from the tracer literature are captured in these tractography reconstructions (47, 48, 20, 49, 50, 10). For instance, the striatal bundle ...

Background: The subthalamic nucleus is the preferred target for deep brain stimulation in patients with advanced Parkinson’s disease. The site of permanent stimulation is the subject of ongoing debate ...