Viruses are microscopic pathogens composed of genetic material housed within a protective protein shell. While they carry the ...

Cyclin-dependent kinases (CDKs ... catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related proteins, but they are still known as ...

INX-315 is an oral, investigational selective cyclin-dependent kinase 2 (CDK2) inhibitor. The designation was based on preclinical data as well as interim data from the ongoing phase 1/2 INX-315-01 ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

"We are excited to outline a clear path for Zentalis to bring azenosertib to patients with Cyclin E1+ PROC,” said Ingmar Bruns ... azenosertib has been well tolerated and has demonstrated anti-tumor ...