SMC (structural maintenance of chromosomes) protein complexes are ring-shaped molecular motors essential for genome folding. Despite recent progress, the detailed molecu ...

Can you imagine a life-saving molecule whose “twin” is a deadly poison? As surprising as it may seem, this chemical reality is known as “chirality”. Like a right hand and a left hand, two molecules ...

An easy method for efficiently identifying proteins that interact with bioactive molecules has been developed by chemical biologists at RIKEN. This innovation, published in ChemBioChem, could help to ...

An unusual DNA structure may hold the key to treating one of the deadliest cancers affecting women, which claims more than ...

One of the greatest revolutions in the field of pain medication was the isolation of morphine from the opium poppy in the ...

Professor Sir Shankar Balasubramanian, from Cambridge, has won the Royal Society of Chemistry’s Khorana Prize in recognition ...

The folded structures of RNA molecules and large ribonucleoprotein particles are stabilized by a wide range of base pairs that actively utilize the 2′-OH groups of ribose for base pairing. Such base ...

Moreover, the model can be enhanced by incorporating experimental binding data and can be generalized to enable base-pair resolution predictions of genomic DNA-binding sites.

Using complementary DNA base-pair interactions, the system functions like a fish biting a hook, forming a catch bond.

Credit: Kateryna Kon/Science Photo Library/ What is DNA, and how does it work? You don't need a degree in genetics to understand. Here, we'll give an overview of DNA and answer questions ...

How can you write data to DNA without changing the base sequence? A new method lets anyone with a kit write data to DNA with just one enzyme.

While the DNA backbone has a similar structure to that of B-form DNA in the ATPase region (Appendix Fig. S1), the base pairing toward the Lon domain is less clear due to the lower resolution of the ...