When Kim characterized the mice, he found this G51D mouse model fully recapitulates the progression of Parkinson's disease in a manner that is similar to how it develops in humans.

Researchers have developed a new mouse model of Hirschsprung's disease and associated enterocolitis and shed light on the disease progression. About one in every 5,000 babies is born without ...

Researchers have developed the first truly accurate mouse model of celiac disease. The animals have the same genetic and immune system characteristics as humans who develop celiac after eating gluten.

That may be because most mouse models of Alzheimer's disease harbor the Swedish mutation. This has so far hindered efforts to study the beneficial effects of the Icelandic mutation.

With this awareness, more than a decade ago Dr. Saido launched a project to develop a new mouse model that would allow more accurate evaluation of therapies for the disease. One of the major ...

The disease has both genetic and nutritional components, which have been hard to understand in human studies, and murine models until now had not accurately reflected typical characteristics of human ...

“In celiac, the main feature of disease is tissue destruction of the small intestinal lining,” said Valerie Abadie, a research assistant professor at UChicago and lead author of the study. “This new ...

This mouse model will now allow the team to study the mechanisms of the disease and to find the most effective treatments. "Although novel treatments are being developed to minimize the side ...

“These mice provide a valid model of Parkinson disease and are a resource for the investigation of pathogenesis and therapeutics,” write the authors. First author Yanping Li and colleagues used ...

In Norway, all newborn children are tested for 25 rare genetic diseases through the Newborn Screening program, and the most common of these is phenylketonuria (abbreviated to PKU), known as ...

Mice and other animals have been key to some of the biggest medical breakthroughs in human history. But animals aren’t always good models of human disease, leading to failed experiments and ...

Two major studies by international teams published today (June 26) show the value and potential of genetically modified mice in biomedical research — and also the pitfalls of conducting research with ...