Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

Researchers from the University of Warwick and University of Manchester developed a machine learning-based model to enhance cryoprotectant discovery. The new approach identifies molecules that prevent ...

The team also conducted experiments using blood, demonstrating that the amount of conventional cryoprotectant required for blood storage could be reduced by adding the newly discovered molecules.

Here, authors developed machine learning models to predict ice recrystallisation inhibition by small molecules, showcasing a data-driven approach for cryoprotectant discovery.

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...