In the ever-evolving realm of injectable skincare, a new contender has emerged: polynucleotides. But what exactly are they, and do they live up to the hype swirling around them, especially in ...

OptE is predicted to be a transmembrane effector protein that binds cyclic nucleotides. optSE potently restricted phage replication but mutant phages that had loss-of-function mutations in anti-CBASS ...

Perrett, R.M. and McArdle, C.A. (2013) Molecular Mechanisms of Gonadotropin-Releasing Hormone Signaling Integrating Cyclic Nucleotides into the Network. Frontiers in Endocrinology, 4, Article 180.

Claudino, M.A. and Fertrin, K.Y. (2012) Sickling Cells, Cyclic Nucleotides, and Protein Kinases The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia. Anemia, 2012, Article ID 723520.

Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by ...

Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression.

References 1. Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013;339:786-791.

Every basic biology lesson teaches that proteins are made up of combinations of 20 distinct amino acids, which are ordered in various patterns similar to words.

Key features of <i>P. aeruginosa</i> are its ability to form biofilms and its resistance to several antibacterial drug classes. A known regulator of biofilm formation is bis- (3′,5′)-cyclic guanosine ...

Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology, 2024; DOI: 10.1038/s41594-024-01220-x ...

Abstract 3′,5′-Cyclic nucleotides are acrasins for the cellular slime mold, Dictyostelium discoideum; they have chemotactic activity on the myxamoebae at very low concentrations. However, not all ...

3′,5′-Cyclic nucleotides are acrasins for the cellular slime mold, Dictyostelium discoideum; they have chemotactic activity on the myxamoebae at very low concentrations. However, not all cyclic ...