Many cellular processes are regulated by cyclic nucleotides through their binding to and activation of protein kinase A, protein kinase G, ion channels and Epac. Recent structural insights have ...

Indeed, in 1971, much of what was known about cyclic nucleotides could be summarized in two monographs 1,10. Beginning around 1971, there was an explosion of activity and interest.

Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology , 2024; DOI: 10.1038/s41594-024-01220-x Cite This Page : ...

Nucleotides, such as cyclic AMP (cAMP) and cyclic GMP (cGMP), function as second messengers in cell signaling pathways. They relay signals from extracellular stimuli to intracellular targets, ...

OptS is predicted to synthesize a second messenger using a minimal CRISPR polymerase (mCpol) domain, a version of the polymerase domain found in Type III CRISPR systems (Cas10) that is distantly ...

That extra bond makes cyclic nucleotides more reactive, though, and thus they were able to join together into long chains at a decent rate (about 200 hours to reach 100 nucleotides long).

The cyclic GMP–AMP synthase (cGAS) enzyme binds to viral DNA, tumor DNA, or our own aberrant DNA. DNA binding activates cGAS to synthesize cyclic GMP–AMP (cGAMP) from ATP and GTP nucleotides.

We are at a critical time and supporting climate journalism is more important than ever. Science News and our parent organization, the Society for Science, need your help to strengthen ...

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502-27508. doi: 10.1073/pnas.2015919117 ...

Cyclic nucleotides (e.g. cAMP and cGMP) are ubiquitous second messengers which affect various cellular functions. Photoactivated adenylyl cyclase (PAC) and guanylyl cyclase rhodopsin (Rh-GC) increase ...