Other orally administered water-soluble phosphate ester prodrugs include estramustine phosphate, prednisolone phosphate, and fludarabine phosphate (Fludara; Bayer) (Table 2). Improved lipophilicity.

Cyclic adenosine 3’,5’-monophosphate (cAMP) is a versatile secondary messenger that communicates with Guanine Nucleotide Exchange Factor (EPAC) to transfer cellular signaling and regulates numerous ...

Cyclic GMP, produced in response to nitric oxide and natriuretic peptides, is a key regulator of vascular smooth muscle cell contractility, growth, and differentiation, and is implicated in opposing ...

Objective Anti-citrullinated protein antibodies (ACPA) and anti-cyclic citrullinated peptide (anti-CCP) antibodies are a hallmark of rheumatoid arthritis and are believed to play a role in disease ...

Calibrating large phased arrays with numerous elements presents a significant technical challenge. In this paper, a novel calibration method for large phased arrays is proposed, utilizing the rotating ...

Cyclic peptides, with unique structural features, have emerged as new candidates for drug discovery; their association with human serum albumin (HSA; long blood half-life) is crucial to improve drug ...