During S phase, pre-RCs initiate replication by promoting origin unwinding and facilitating recruitment of the replicative DNA polymerases.

During S phase, any problems with DNA replication trigger a ‘' checkpoint " — a cascade of signaling events that puts the phase on hold until the problem is resolved.

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer.

When does DNA replication occur? DNA replication occurs in the S phase of the cell cycle. DNA replication is the process where DNA copies itself. This happens so that old cells can make new cells.

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

Brian and Helle speculate this may be because the additional RER activity of RNase H2 creates nicks in the DNA, which are a risk for double-strand breaks during DNA replication in S phase.

The actual DNA replication occurs during the synthesis (S) phase, when two copies of the original cell DNA are produced, each containing one original and one new strand of DNA.

Scientists have discovered that a protein known as Cdt1, which is required for DNA replication, also plays an important role in a later step of the cell cycle, mitosis. The finding presents a ...

Maternal and paternal DNA replication patterns are different In their new study, the researchers studied the DNA replication patterns in early embryos.

These new details about the early stages of DNA replication not only answer fundamental biological questions about how the process works, but also potentially explain how errors can lead to disease.