In vivo base editing enables precise, single-nucleotide changes to DNA without double-strand breaks. A recent application in ...

The discovery may explain why cutting edge CAR T-cell therapy has managed to revolutionized treatment for blood cancer but ...

Scientists with the NIH-backed SMaHT Network are mapping every DNA mutation in the human body, creating a groundbreaking ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break ...

New blood tests can detect cancer recurrence earlier than traditional scans, potentially giving doctors and patients crucial information to make decisions about treatment. But more studies are needed ...

During repair, the DNA reads the uracil as thymine. Although there's no double-stranded break, base editors do create a nick in one strand.

Base editing, which corrects misspellings in DNA, offers an alternative to existing forms of gene therapy, which either add or remove things from the genome. Beam Therapeutics ...

Using a point-mutation strategy, the researchers revealed that Mg 2+ is essential for the complex's DNA cleavage activity. Knock-in mice carrying a SPO11 point-mutation that disrupts Mg 2+ binding ...

It also detects single-strand cytosine deamination events, a common type of DNA damage. Since the double-strand DNA mutations interrogated by prior studies are only the endpoint of the mutation ...