In vivo base editing enables precise, single-nucleotide changes to DNA without double-strand breaks. A recent application in ...

Fourteen million people worldwide suffer from enlarged hearts, or hypertrophic cardiomyopathy (HCM), a genetic disease that ...

The discovery may explain why cutting edge CAR T-cell therapy has managed to revolutionized treatment for blood cancer but ...

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations Suet Nee Chen, Raffaella Lombardi, Jennifer ...

Scientists with the NIH-backed SMaHT Network are mapping every DNA mutation in the human body, creating a groundbreaking ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Moving toward clinical development, the researchers demonstrated efficient delivery of mRNA mitochondrial base editors using ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

Importantly, neither WIP1 mutations nor knockout prevent p53-dependent G1-arrest in response to prolonged mitosis in the absence of DNA damage. Prolonged mitosis and G2-DNA damage thus promote ...

A new study published in Aging Cell reveals that a well-known enzyme, long known for its involvement with cancer, actually steps into the nucleus to help repair DNA. This enzyme is Protein Disulphide ...

The translocation of DNA in polymerases (Pols) is an essential molecular process in cells, enabling DNA replication and transcription. (1,2) This process occurs at every catalytic cycle in Pols after ...

Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and ...