Billions of years ago, a rock crack exuding heat could have brought different biomolecules together to kickstart protein ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Reducing our intake of a single amino acid called methionine, which we get from the food we eat, could help protect against ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

Human 8-oxoguanine-DNA glycosylase (hOGG1) possesses very high specificity for 8-oxoguanine (oxoG), even though this damaged base differs from normal guanine by only two atoms. Our aim was to ...

Technical Report Published: July 2000 Seamless gene engineering using RNA- and DNA-overhang cloning Vincent W. Coljee, Heather L. Murray, William F. Donahue & Kevin A. Jarrell Nature Biotechnology ...

Additionally, we found that RNA aids in double-strand break repair in both yeast and human cells, suggesting that its role in DNA repair is evolutionarily conserved across species.

We found that RNA can actively guide the repair process of double-strand breaks. It does this by binding to broken DNA ends, helping align sequences of DNA on a matching strand that isn’t broken.

Pseudoisocytosine (J), a neutral analogue of protonated cytosine, is currently the gold standard modified nucleobase in peptide nucleic acids (PNAs) for the formation of J·G-C triplets that are stable ...

At an alkaline pH, amino acids exist in both neutral and negatively charged forms, enabling them to shuttle protons in the polymerization reaction that forms RNA from ribonucleoside 2′,3′-cyclic ...