Finding a way to disable the efflux transporters of M. tuberculosis with an inhibitor would strike a double blow — restore microbial sensitivity to antibiotic bedaquiline and break the cycle that ...

More information: Jennifer C. Earp et al, Structural basis of siderophore export and drug efflux by Mycobacterium tuberculosis, Nature Communications (2025). DOI: 10.1038/s41467-025-56888-6 ...

The proteins MmpL5 and MmpL4 are efflux transporters, critical pumps that help the pathogen M. tuberculosis grow by scavenging essential iron from the iron-deprived lung granulomas of its human host.

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Efflux pump-mediated resistance to new beta lactam antibiotics in multidrug-resistant gram-negative bacteria Dulanto Chiang and Dekker discuss recent work on efflux pump-mediated antibiotic ...

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Iii) treatment with efflux pump inhibitor sertraline and verapamil (even though some caution needs to be taken since it is not perfectly selective, see weakness) prevents generation of low ...

Webber, M.A. (2002) The Importance of Efflux Pumps in Bacterial Antibiotic Resistance. Journal of Antimicrobial Chemotherapy, 51, 9-11.

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Heterogeneous expression of efflux pumps within isogenic bacterial populations has been reported 29, 32, 33, 67 – 69. However, recent reports have suggested that efflux is not the primary mechanism of ...