This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Loss of a key immune protein disrupted cell signaling and defense, revealing a novel driver of chronic airway inflammation in ...

Despite their importance, genome-wide CRISPR screening in these primary human cells has been out of reach - until now. “Macrophages and dendritic cells are exceptionally challenging to tackle,” said ...

The increased expression of SLC31A1 promoted cuproptosis of macrophages and elevated tumor necrosis factor-α (TNF-α) secretion, which activated the NLR family pyrin domain containing 3/matrix ...

Tumor-associated macrophages (TAMs) and epithelial-mesenchymal transition (EMT) are key drivers of lung cancer metastasis and drug resistance. M2-polarized TAMs dominate the immunosuppressive tumor ...

Infection of the respiratory system by diseases like COVID-19 and flu causes damage to the epithelium. During the healing process, regenerative cells are typically kept in check by macrophages, as ...

In aging mice, senescent cells in the choroid plexus recruited circulating macrophages. These immune cells released a protease, cathepsin S, that chewed up claudin 1, part of the glue that seals ...

The following is a summary of “Signaling lymphocytic activation molecule family 8 disrupts epithelial barrier in chronic rhinosinusitis with nasal polyps through M1 macrophage polarization,” published ...

Clements, D. and Idoyaga, J. (2021) Alveolar Macrophages and Epithelial Cells The Art of Living Together. Journal of Experimental Medicine, 218, e20211583.

Abstract 10 Background: In the realm of tumor progression, the immunosuppressive role of macrophages has been well-established. However, a significant lacuna persists concerning the mechanisms through ...

A little leg may reveal something big about how closely related insect species can drastically differ in body shape, ...