This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Figure 1. Workflow of materials and methods. (A) Isolation and bioinformatic analysis of secretome from CDCs. (B) Differentiation and treatment of macrophages with S-CDCs (C) Functional assays with ...

Loss of a key immune protein disrupted cell signaling and defense, revealing a novel driver of chronic airway inflammation in ...

The researchers then found that when they genetically decreased the macrophages’ ability to consume dying cancer cells, or decreased Upd3 production, tumor growth was significantly reduced.

Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no quantitative measure to ...

Results: Both in vitro and in vivo experiments validated that pMSCs promoted M2 macrophage polarization and reduced the release of inflammatory factors. Further analyses revealed that pMSCs activated ...

Vascular inflammation is associated with and in large part driven by changes in the leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during atherosclerosis, the most common ...

The crucial role of monocyte/macrophage transformation from inflammatory to reparative phenotype in post-MI repair has been demonstrated recently. 14 Mice harboring macrophages with impaired ability ...

Epithelial cells form the skin’s outer layer and line the gut, blood vessels, airways—basically “every single organ in your body that connects to the outside world,” says Ellen Foxman, who ...