These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic ...

Activators of nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and ...

Overall, analysis of this erythroid-specific conditional Atg7 knockout model shows that the absence of Atg7 in erythroid cells is sufficient to reproduce the anemic phenotype of Vav-Atg7 −/− mice; ...

Nuclear factor - erythroid – 2 - related factor 2 (Nrf2) is a vital molecule of the endogenous antioxidant system that plays a central role in stimulating expression of various antioxidant - ...

OBJECTIVE Nuclear factor erythroid-2 related factor 2 (Nrf2)/ antioxidant response element (ARE) is a novel defensive pathway involved in the oxidative and chemical stress of cells. The aim of the ...

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway ...