A new hypothesis called the “quantum memory matrix” could solve long-standing physics questions, including the Black Hole Information Paradox and dark matter.

Genome analysis of non-O1, non-O129 strains have revealed a gene encoding a putative toxin related at the amino acid sequence level (32% identity) to exotoxin A of Pseudomonas aeruginosa.

Using a range of computational tools the mechanism of action of the toxins are explored, and new inhibitors targetting the NADP binding site identified using in silico docking teachniques. Together ...

Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality globally. Elevated levels of serum LDL-C (low-density lipoprotein cholesterol) represent a significant risk factor ...

Key Exosomes Companies: Innovex Therapeutics, Coya Therapeutics, EV Therapeutics, Endosome Therapy StemXO Therapeutics, Brexogen, ILIAS Biologics, Organicell Regenerative Medicine, Codiak ...

Early endosome maturation requires Rab conversion and ESCRT function; however, how these processes are coordinated remains largely elusive. This study proposes that Rab conversion in both C. elegans ...

"Escaping the endosome: Bend lipids improve LNP mRNA delivery and gene editing." ScienceDaily. ScienceDaily, 28 January 2025. <www.sciencedaily.com / releases / 2025 / 01 / 250128123934.htm>.

Escaping the Endosome Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically captured by endosomes — tiny protective sacs within the cell.

(A) A selection of SNARE proteins from yeast and mammals were aligned with proteins with SNARE-like motifs, and a 53-residue stretch of sequence is shown. Proteins are grouped by Q-SNARE, R-SNARE, or ...

Biozentrum, University of Basel, Basel, Switzerland Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of protein and lipid cargoes to counterbalance anterograde ...

A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation. The research team was led by Dr. Ding Mei and Dr. He Kangmin from the ...