Protein-DNA interaction is of fundamental importance in molecular biology, playing roles in functions as diverse as DNA transcription, DNA structure formation, and DNA repair. Protein-DNA association ...

Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce it in fruit flies, extending healthy lifespan by 25% to 30%. The ...

Decision letter after peer review: Thank you for submitting your article "ERK3/MAPK6 dictates Cdc42/Rac1 activity and ARP2/3-dependent actin polymerization" for consideration by eLife. Your article ...

Uncovering the similarities and differences between these two mechanisms is fundamental to understanding how actin cytoskeleton dynamics are regulated. Here, analysis of individual filaments reveals ...

This new study revealed that, in glucose-starved SLC7A11-high cancer cells, the large number of accumulated disulfide molecules cause aberrant disulfide bonding among actin cytoskeleton proteins ...

Researchers from Cleveland Clinic's Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a "priming signal" for the body ...

These results suggest that the role of Rab35 in actin cytoskeleton structuration requires the downstream activity of the Arp2/3-complex for the formation of the lamellipodia and the defects produced ...

Rac and Arp2/3-Nucleated Actin Networks Antagonize Rho During Mitotic and Meiotic Cleavages Debadrita Pal 1 Andrea Ellis 1 Silvia P. Sepúlveda-Ramírez 1 Torey Salgado 1 Isabella Terrazas 1 Gabriela ...

Adults with spinal muscular atrophy (SMA) type 3 have significantly lower levels of several molecules that help regulate actin, one of the major components of the cell’s cytoskeleton, according to a ...

In a new study, University of Maryland researchers have demystified the process by which cells receive their shape—and it all starts with a protein called actin.

In the other mode (Fung et al (2019) J. Cell Sci.), mitochondrial depolarization causes rapid accumulation of an extensive ‘shell’ of actin filaments around the depolarized mitochondria, dependent on ...