This has been overcome by "humanization" of murine antibodies, which involves the transfer of complementarity determining regions (CDRs) from the murine antibody along with some adjacent framework ...

In a paper recently published on hLife, Chinese scientists elucidate the 3.04 Å cryo-EM structure of HSV-1 gB bound to the neutralizing antibody D48. Through structural and sequence comparison ...

Of note, IgG1, IgG2a, and IgG2b anti-TNP antibodies protected against renal disease in mice injected with TNP–protein conjugate plus IgG3 anti-TNP, with IgG1 being the most protective.

Retrained generic antibodies can ... "We investigated potential COVID-19 therapeutics using computer simulations based on the X-ray crystal structure of the receptor-binding domain of SARS ...

Three fully human IgG1 antibodies with varying levels of affinity are ideal for use as surrogate positive controls or calibrators in anti-drug antibody assays. These are complemented by a TrailBlazer ...

PBA-0405 is a fully human IgG1 antibody that was discovered using Twist Biopharma Solutions’ synthetic antibody phage display libraries. Twist Biopharma Solutions, a divis.

Delivery of protein therapies to the brain has proven difficult because of the need to cross the blood–brain barrier (BBB). Now, two recent papers from researchers at Denali Therapeutics ...

As of 2006 there were 18 monoclonal antibodies approved for therapeutic use in US, and 14 of them were molecules of the IgG isotype. Among these, 50% are humanized IgG1 anti-bodies. The antibody ...