Antibody-drug conjugates (ADCs) represent a mechanistically defined class of targeted therapeutics that combine monoclonal antibodies with cytotoxic payloads to achieve selective delivery to ...

In some studies, a positive correlation was reported, 196 – 198 whereas a negative relationship was found in some others. 199 In animal models, immunization protocols using MDA-modified LDL led to ...

Arialys Therapeutics' precision medicine has shown preclinical potential to address the underlying cause of anti-NMDA receptor encephalitis (ANRE), a rare brain disorder that comes with severe ...

Enhanced ADCC (antibody-dependent cellular cytotoxicity): The engineered dimeric IgG1 backbone not only delivers payload but actively engages the immune system to kill tumor cells directly.

ART5803 is a humanized, monovalent IgG1 antibody engineered to selectively bind the GluN1 subunit of the NMDA receptor without disrupting receptor function or causing internalization.

DeepBioLab is an AI-focused platform designed to explore, build, and share advanced AI algorithms. It features educational content, projects, and research on topics like deep learning, reinforcement ...

Results Prominent reactivity against a 56 kDa protein was detected in human H69 cholangiocyte lysates exposed to sera of nine patients with IAC/AIP. Affinity purification and mass spectrometry ...

Both 6B2 tau antibody and IgG1 were also taken up in a time-dependent manner (Figures 6A, 7A), and distinctly localized in the neurites and more distal processes of the DC, with limited visibility in ...