Analysis of metabolite and enzyme expression levels revealed that the increased lipid content of MA-GAPDH1 was due to enhanced flux of glyceraldehyde-3-phosphate to glycerate-1, 3-biphosphate.

Inhibiting sphingosine-1-phosphate receptor 3 (S1pr3) mitigates pulmonary fibrosis S1pr3 knockdown ameliorates bleomycin-induced pulmonary fibrosis by reducing macrophage M2 polarization ...

Glycerol-3-phosphate acyltransferases (GPAT) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two ...

eLife Assessment This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is ...

A crucial molecule for brain health acts as a garbage collector of other fat molecules (lipids), despite also being a lipid ...

Scientists have gained a deeper understanding of a molecule that regulates lipid levels in the brain. This breakthrough could ...

The 1 Acylglycerol 3 Phosphate O Acyltransferase PNPLA3 pipeline drugs market research report outlays comprehensive information on the 1 Acylglycerol 3 Phosphate O Acyltransferase PNPLA3 targeted ...

Diez-Fernandez, C., & Häberle, J. (2017). Targeting CPS1 in the treatment of Carbamoyl phosphate synthetase 1 (CPS1) deficiency, a urea cycle disorder.

BXQ-350: Modulating ceramide and sphingosine-1-phosphate for antitumor activity in patients with advanced CRC. Authors: Olivier Rixe, Richard Charles Curry, John Charles Morris, Carolyn Muller, Anne M ...