The study looked at a drug called spironolactone. It’s normally used to treat high blood pressure, but it’s now showing ...

The glycocalyx is a soft, protective coating that lines the inside of all blood vessels. It helps control how fluids and nutrients pass from the blood into nearby tissues, including the heart muscle.

To the point Protective layer around cilia: The layer known as glycocalyx consists of sugar-rich proteins (glycoproteins) and influences the mobility and signal transduction of cells. Main components: ...

Bottlebrush Barrier. The glycocalyx layer (purple, left) that coats brain blood vessels consists of numerous glycoproteins, glycolipids, and proteoglycans (right), including the bottlebrush-shaped ...

This thinning of the glycocalyx correlated with increased permeability of the blood-brain barrier and heightened neuroinflammation. When the team reintroduced those critical mucins in aged mice, ...

The glycocalyx coats BBB’s luminal surface and mediates many processes, including cell signaling, transport, morphology, and adhesion. However, little is known regarding the functional roles and ...

“The glycocalyx is like a forest,” Shi explains. “In young, healthy brains, this forest is lush and thriving. But in older brains, it becomes sparse, patchy, and degraded.” ...

Neuroscience How a carbohydrate-rich mesh protects our brain Study investigates the sugary-rich layer of the blood brain barrier and the link between its degradation and dementia by Laura Howes ...

Researchers at the University of Gothenburg have uncovered a critical mechanism that may pave the way for innovative treatments for Crohn's disease. Their findings center on repairing the protective ...

The endothelial glycocalyx is a multifaceted structure that acts as a dynamic regulator in various physiological and pathological processes. From regulating blood flow and endothelial functionality to ...