New drugs that target "zombie" tuberculosis (TB) cells are now a step closer, thanks to a new study led by the University of ...

Background In 2011, there were approximately two million cases of hospital-acquired infections in the United States, more than 75,000 of which were fatal. [1] Gram-negative bacteria cause the four ...

Abstract Due to the emergence of multidrug resistant bacteria, the development of new antibiotics is required. We introduce here asymmetrically modified positively charged bis (methylpyridinium) ...

Combination therapy with membrane-targeting compounds is at the forefront because the bacterial membrane is an attractive target considering its role in various multidrug-resistant elements. However, ...

Appropriate use of antibiotic therapy was defined heterogeneously among 68 % of included studies using both susceptibility and timeliness. About 20 % of studies reported susceptibility to at least ...

A 7-day course of antibiotic therapy may be comparable to a 14-day course for reducing the risk of mortality in patients with uncomplicated gram-negative bloodstream infections (GN-BSIs), according to ...