Specific MEF2 isoforms play important transcriptional regulatory roles in myogenesis (Black and Olson, 1998; McKinsey et al., 2002), cardiac differentiation and metabolism (McKinsey et al., 2002 ...

One HDAC target is MEF2, a key muscle transcription factor. Given that HDAC–MEF2 interaction is known to repress MEF2 (ref. 6) activity and MEF2 has been implicated in cardiac hypertrophy 6, ...