ARO-C3 is an investigational RNA interference therapeutic designed to reduce liver production of complement component 3 as a potential therapy for various complement-mediated diseases.

The increasing demand for donor hearts presents both a critical challenge and a significant opportunity for innovation in ...

Biologics revolutionize generalized myasthenia gravis care with fast-acting, patient-friendly therapies and a robust global pipeline redefining outcomes. The gMG treatment era is shifting rapidly-from ...

Cryoglobulins containing IgG, IgM and complement have been described in the serums of patients with SLE. 6 Such cryoglobulins have been found to have an anticomplementary effect, 8 and ...

Although it has been established that IgM is more potent in anti-bacterial immunity than IgG, the mechanisms by which human IgM can achieve this remains elusive. Using monoclonal human IgM targeting ...

Patients with IgG4-related disease exhibited a distinct platelet activation profile, with 22 platelet-specific genes significantly altered. Patients with immunoglobulin G4-related disease (IgG4-RD) ...

A new study has found that hypocomplementemia in patients with immunoglobulin G4-related disease (IgG4-RD) reflects disease severity beyond renal involvement, and that complement activation likely ...

Researchers present structures of ZIKV NS1 in complex with five human antibodies at 2.6–2.9 Å resolution. The structural and biochemical results elucidate the correlation between epitope ...

Levels of C4a, a cleaved product formed with the activation of the classical complement pathway, were 19% higher in people with CIS than symptomatic controls. CIS is the first clinical ...

Complement activation by immune complexes can result in release of complement 3a, complement 4a, and complement 5a anaphylatoxins that can cause histamine release via an IgE independent mechanism. 11 ...

“The IgG antibody-induced complement activation and neuronal apoptosis may be a novel mechanism for axonal loss and neuronal degeneration in MS,” the researchers noted.