ARO-C3 is an investigational RNA interference therapeutic designed to reduce liver production of complement component 3 as a potential therapy for various complement-mediated diseases.

Complement activation by CRP differs from complement activation by IgG in producing a selective activation of early components without the formation of the membrane attack complex (MAC).

Immunoglobulin gamma autoantibodies directed against myelin oligodendrocyte glycoprotein (MOG-IgG) are associated with specific neurological syndromes, most frequently acute disseminated ...

Figure 1. Complement and TLR involvement in dysbiosis and inflammatory bone loss in periodontitis. The classic, lectin, and alternative pathways converge at and activate the central complement ...

The LE cell reflects the unique immune environment in SLE and is basically a cell nucleus that has been opsonised by an ANA and complement and is then engulfed by a neutrophil. 2 The key players for ...

Biologics revolutionize generalized myasthenia gravis care with fast-acting, patient-friendly therapies and a robust global pipeline redefining outcomes. The gMG treatment era is shifting rapidly-from ...

Article Published: January 2001 Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy Andrew L. Mellor, Jayabalan Sivakumar, Phillip ...

Complement activation by anti-PEG IgG largely depended on the alternative complement pathway, regardless of the PEG density on the liposomes. Inhibition of the classical complement pathway, which ...

ICE to activate Special Response Teams in 5 cities, including Chicago: Sources The "elite special response teams" also known as SRTs, are part of ICE’s Enforcement and Removal Operations department.

This story was excerpted from Kennedi Landry's Rangers Beat newsletter. To read the full newsletter, click here. And subscribe to get it regularly in your inbox. MINNEAPOLIS -- Evan Carter, who was ...

Surface-bound NP mediates classical complement activation through anti-NP antibodies (Abs) from COVID-19-recovered individuals. Credit: Cell Reports (2025). DOI: 10.1016/j.celrep.2025.115512 ...