Researchers discovered that HSV-1 (herpes simplex virus) actively reshapes the 3D layout of human DNA within hours of ...

Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

Cold sore virus hijacks human genome in 3D--and scientists found its weak spot HSV-1 reshapes the human genome for its own benefit. Targeting a host enzyme can completely halt the hostile takeover ...

This study has shown that HSV-1 is an "opportunistic interior designer" of human cells. | Genetics And Genomics ...

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the ...

While other herpes viruses have been seen compacting and reshaping host chromosomes, it was unclear whether it was a side effect of the virus invading and setting up its own viral replication ...

Human DNA in its natural state inside cells (left) compared to eight hours after being infected with HSV-1 (right). The virus compacts the human genome's size significantly and moves it towards ...

Topoisomerase I, an enzyme that snips DNA to release torsional stress, and cohesin, a structural protein, followed human RNA-polymerase II into the newly forming viral replication compartments.

The cold sore-causing Herpes Simplex Virus (HSV-1) hijacks human cells and reconfigures its DNA within just an hour after ...

After invading host cells, the virus replicates in the nucleus, where genetic material is stored within strands of DNA. These strands wrap around proteins, with some regions forming tight coils ...

Lithgow’s team started by sequencing the strain’s genome. It’s fairly straightforward to get a good readout of a bacterium’s genetic code using short-read sequencing, which involves fragmenting the ...

Whether antiretroviral therapy (ART) is always completely suppressive, or HIV might continue to replicate at low levels despite ART in some people with HIV (PWH), is still debated. Here, we ...