Tubular and interstitial cells in the juxtamedullary region and outer medulla are, even under normal conditions, in a state of relative hypoxia.

These tumors account for 0.8%-1.1% of all primary spinal tumors with the majority occurring in the extramedullary or subdural juxtamedullary lumbosacral region, usually in the conus or cauda equina ...

Injury of the juxtamedullary afferent arterioles (the ‘strain’ vessels) and glomeruli, of which microalbuminuria is a marker, may impair downstream medullary circulation through the vasa recta.

36 Guan ZCA, Inscho E. Effect of ENaC blockade on the myogenic response of rat juxtamedullary afferent arterioles. FASEB J. 2007; 21: 595.15. Abstract. Google Scholar 37 Meltzer RH, Kapoor N, Qadri YJ ...