Two new landmark studies show how a seeming tangle of DNA is actually organized into a structure that coordinates thousands of genes to form a sperm cell. The work, published March 3 as two papers in ...

Reference:Lokareddy RK, Hou CFD, Forti F, et al. Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. Nat Commun. 2024;15 (1):8482. doi: 10.1038/s41467-024-52752-1 ...

In the current study, the scientists installed up to five distinct mutations on a single lambda phage genome without counterselection in only a few hours of hands-on time.

More information: Chloe B. Fishman et al, Continuous multiplexed phage genome editing using recombitrons, Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02370-5 ...

Scientists have assembled the most complete woolly mammoth genome in 3D, thanks to an incredible “freeze-dried” specimen. With its DNA preserved in a glass-like state, chromosomes were found ...

Thanks to the newly discovered flash-frozen DNA, this mammoth project—pun intended—is the first to assemble an enormous ancient genome in 3D. “This is a new type of fossil, and its scale dwarfs that ...

In this study, they found that the lambda phage shares this mechanism. If the DNA slips to the extent that it would completely fall out, it is caught by its end and prevented from detaching from ...

In this study, they found that the lambda phage shares this mechanism. If the DNA slips to the extent that it would completely fall out, it is caught by its end and prevented from detaching from ...

Once phages attach to a host, they pursue either a lytic or lysogenic replication strategy. 2 In lytic replication, the phage introduces its viral genome into the cytoplasm and uses the host cell ...

For E. faecalis, which is a Gram-positive uropathogen, a phage-derived chimeric cell wall-hydrolase (EC300) was employed that recognized and disrupted the bacterial cell walls with high specificity.