Seminal studies from our group and others have demonstrated that macrophages in MI tissue display phasic functional heterogeneity and contribute essentially to postinfarction healing process. 3–9 ...

Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Tumor associated macrophages (TAMs) are pivotal in the tumor microenvironment, influencing angiogenesis, metastasis, and immunosuppression. This study explores macrophage polarization using a ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and activation. Unlike ADA1, which primarily functions intracellularly, ADA2 can be ...

Results CD68 (a macrophage marker) and NLRP6 expression were detected in patient HCC tissues, and patients with lower macrophage NLRP6 expression had longer survival. Compared with their wild-type ...

This study for the first time investigated how pharmacological inhibition of TRPV4 combined with mechanical strain influences the polarization and function of M1 macrophages within 3D collagen ...

Finally, Alexa Fluor 488-conjugated phalloidin and Hoechst 33342 were used to stain the cytoskeleton and nuclei, respectively to observe macrophage morphological changes. The macrophage polarization ...

Finally, Alexa Fluor 488-conjugated phalloidin and Hoechst 33342 were used to stain the cytoskeleton and nuclei, respectively to observe macrophage morphological changes. The macrophage polarization ...