Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Tumor associated macrophages (TAMs) are pivotal in the tumor microenvironment, influencing angiogenesis, metastasis, and immunosuppression. This study explores macrophage polarization using a ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

The traditional therapeutic strategy of functionalizing repair materials with immunomodulators, drugs, and chemokines to manipulate macrophage polarization often faces challenges such as undesirable ...

Tumor-associated macrophages (TAMs) polarization and cytokine levels were analyzed by flow cytometry and enzyme linked immunosorbent assay (ELISA). Western blotting and Real-time reverse transcription ...

PG3M@GaPP promotes macrophage polarization to the anti-inflammatory M2 phenotype, enhancing immune modulation and bacterial uptake. The platform’s positive charge facilitates endosomal escape, ...