Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

Conversely, during atherosclerotic plaque regression, the expression of CD68 + inflammatory cells decreases within the plaque, while the expression of M2 macrophage marker genes increases, indicating ...

View This Abstract Online GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis. Inflamm Res. 2023; 72 (10-11):1941-1955 (ISSN: 1420-908X) ...

Recent advances indicate that immune imbalance—specifically the skewed polarization of macrophages toward a pro-inflammatory state—plays a critical role in disease severity.

IL-10 and TNF-α, as key anti-inflammatory and pro-inflammatory factors of macrophages, respectively, play essential roles in regulating immune responses view more Credit: Xiao Lab@ GMU.

Macrophages, which accumulate in tissues during inflammation, may be polarized toward pro-inflammatory (M1) or tissue reparative (M2) phenotypes. The balance between these phenotypes can have a ...

Abstract Non-alcoholic fatty liver disease (NAFLD) is a pathological condition affecting individuals worldwide. Patients with NAFLD are more susceptible to systemic inflammation, such as sepsis, which ...

Reviewer #2 (Public Review): Summary: The authors investigated systemic inflammation induced by LPS in various tissues and also examined immune cells of the mice using tight junction protein-based PDZ ...