Macrophage-mediated inflammation drives autoimmune and chronic inflammatory diseases. Treatment with anti-inflammatory agents can be an effective strategy to reduce this inflammation; however, high ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

Previous studies suggest that natural compounds, including cordycepin, and Sargassum fusiforme polysaccharides, have the potential to modulate macrophage polarization, shifting the immune response ...

Hematopoietic stem and progenitor cells (HSPCs) polarize in contact with the bone marrow stromal cells constituting their niche. Given the role of cell polarity in protection against tumorigenesis and ...

As a proof of concept, we herein report a biomimetic plaque-targeting M2-exosome (E)/liposome (L) nanohybrid coencapsulated with atorvastatin (A) and ferrostatin-1 (F) (named EL@AF), which exhibits ...

Subsequently, we examined how M1 macrophages, known to contribute to skin inflammation during photoaging, affect NHDF through their conditioned medium. Treatment of NHDF with M1-conditioned medium (M1 ...

However, with our samples, this comes at the cost of depleting macrophages and inducing an inflammatory shift in the single-cell transcriptome. We have not investigated the optimal pre-FACS treatment ...