Multiple myeloma is almost always preceded by an asymptomatic premalignant stage known as monoclonal gammopathy of undetermined significance (MGUS). About 1% of patients with MGUS progress to SMM ...

For decades, the diagnosis of multiple myeloma required evidence of end-organ damage characterized by myeloma-defining events (MDEs) known as CRAB: C=Hypercalcemia R=Renal insufficiency A=Anemia B ...

By MELINDA J. OVERSTREET for Glasgow News 1 In September 2023, he had been fighting a cold for weeks and weeks. His immune ...

CT scans showed mass in thoracic spine 6–8, vertebral fracture, and left pleural effusion. This patient was diagnosed as IgA-λ MM at the DS IIIA stage (or ISS III, R-ISS III stage with EMD), ...

Multiple myeloma causes lytic or osteolytic lesions, which are areas of damage caused by cancerous plasma cells blocking normal bone growth. While painful, they can be managed. Multiple myeloma is ...

Pfizer is conducting a critical Phase 3 clinical trial for the drug elranatamab, targeting relapsed or refractory multiple myeloma. The trial compares elranatamab alone and combined with daratumumab ...

Both BMY’s Pomalyst and Revlimid are approved for multiple myeloma. Sanofi is also evaluating a fixed-dose subcutaneous (“SC”) formulation of Sarclisa for the treatment of R/R MM.

The first successful application of a similar procedure, ie, vertebroplasty was published in France by Deramond et al in 1987 in a patient who suffered a vertebral fracture from osteolysis caused ...

About Multiple Myeloma Multiple myeloma is a challenging and potentially deadly blood cancer that involves plasma cells, a type of blood cell that helps to fight infection. It is the second most ...

Protein arginine methyltransferase 4 (PRMT4) is highly expressed in relapsed or refractory multiple myeloma (MM) and is associated with poor prognosis. Conventional PRMT4 inhibitors face challenges ...

Signs and Symptoms That Occur With Multiple Myeloma As cancerous plasma cells multiply within the bone marrow, they reveal their presence in a number of ways. The main three tend to be: Bone Pain ...