Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Tumor associated macrophages (TAMs) are pivotal in the tumor microenvironment, influencing angiogenesis, metastasis, and immunosuppression. This study explores macrophage polarization using a ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in ...

This letter presents a new formulation of the integral interconnection and damping-assignment passivity-based control methodology for underactuated mechanical systems subject to both matched and ...

The traditional therapeutic strategy of functionalizing repair materials with immunomodulators, drugs, and chemokines to manipulate macrophage polarization often faces challenges such as undesirable ...

The Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for linerixibat for the treatment of cholestatic pruritus in patients with primary biliary cholangitis ...

M2 macrophages act as a pivotal factor in immune regulation, tissue remodeling, wound healing, and angiogenesis (27, 28). 2.2 Effects of different polarization states on AS M1 and M2 macrophages ...

Mitochondrial Metabolic Regulation of Macrophage Polarization in Osteomyelitis and Other Orthopedic Disorders: Mechanisms and Therapeutic Opportunities Provisionally accepted Jinglin Li 1,2 Lin Zhang ...

PG3M@GaPP promotes macrophage polarization to the anti-inflammatory M2 phenotype, enhancing immune modulation and bacterial uptake. The platform’s positive charge facilitates endosomal escape, ...