Pathogenesis of Psoriasis. For most of its history, psoriasis has been thought of as a disease localized to the skin and primarily being driven by abnormalities in keratinocytes.

Neutrophils are also involved in the pathogenesis of psoriasis through their interactions with other immune cells and keratinocytes. Furthermore, studies have identified high levels of iron in the ...

IL-17 is one of the key cytokines in the pathogenesis of psoriasis. Keratinocytes respond to IL-17 by producing a wide range of chemokines, AMPs, and other cytokines, such as IL-6 and IL-1F9.

Overall, patients with psoriasis had a 20% greater risk of organ-based comorbidities (pooled relative risk [pRR], 1.20; 95% CI: 1.11-1.31). Patients with moderate or severe disease were more ...

Psoriasis lesions contained a large number of Th1 and Th17 cells, whereas atopic eczema lesions have higher amounts of Th2 and Th22 cells (Figure 1A and Figure 2A). 11,12 Accordingly, secretion of ...

Psoriasis is a complex disease with a significant genetic component. Twin studies and familial aggregation studies have confirmed the high heritability of psoriasis, with a concordance rate among ...

Access free, up-to-date clinical references on the genetics and pathogenesis of psoriatic arthritis at Healio. We aid in making confident point-of-care decisions.

In one meta-analysis of psoriasis patients, the risk ratio relative to the general population was 1.37 for CVD mortality, 3.04 for myocardial infarction (MI), and 1.59 for stroke.. The relative ...

Scientists believe the hormone hepcidin, when produced in the skin, may be the root cause of psoriasis -- a chronic and sometimes debilitating skin disease that affects 2-3% of the global population.

About the study. The present study used murine models of psoriasis and cell-based experiments to examine the roles of iron and hepcidin expression in the skin in the pathogenesis of psoriasis.