We found that PAX7 was expressed by immunohistochemistry in all 5 ERG-positive Ewing sarcoma cases (5/5, 100%). NKX2-2 was also expressed in each of these cases.

"I previously focused my research on PAX7-positive cells. Our findings lead us down a new path." New muscles despite a mutatio n ...

More information: Andreas Marg et al, Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7, Nature Communications (2019). DOI: 10.1038/s41467-019-13650-z ...

Scientists have discovered a new subtype of muscle stem cells. These cells have the ability to build and regenerate new muscles, making them interesting targets for the development of gene therapies.

Although this method initially achieved an 85% PAX7-positive cell population, successive passaging led to a dramatic decrease in stemness, with PAX7 expression dropping to 16.7% and myogenic ...

The PAX7 stem cells we identified proved highly resistant to cancer treatments, suggesting that they may be the cells responsible for the recovery of fertility following such treatments.

"I previously focused my research on PAX7-positive cells. Our findings lead us down a new path." New muscles despite a mutatio n ...