Gram-positive infections are responsible for approximately 50% of sepsis cases in the USA. 1 In addition to classic sepsis syndromes, several Gram-positive species are also capable of producing ...

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Private equity and venture capital transactions rebounded from their lowest level since January, even as the aggregate deal value declined in the week through Friday, data collated by VCCircle showed.

Site-specific protein bioconjugation methods have enabled the development of new therapeutics and materials, and further development of existing techniques has expanded the compatible library of ...

As exotoxin A, cholix toxin (71 kDa) enters eukaryotic cells via low-density lipoprotein receptor-related protein and probably other membrane receptors, and then catalyzes ADP-ribosylation of ...

For example, SS1P is a murine single-chain Fv, specific for human mesothelin, which has been linked to Pseudomonas exotoxin A (PE), which results in cell death via inhibition of EF2 when ...

Using a range of computational tools the mechanism of action of the toxins are explored, and new inhibitors targetting the NADP binding site identified using in silico docking teachniques. Together ...

Short-term high-fat diet feeding plus acute ethanol binge induced acute liver injury in mice via oxidative stress, inflammation and pyroptosis ...